Measurement
How energy expenditure is actually measured
Doubly labelled water is the reference method, and it shows far less between-person variation than folklore predicts.
Metabolismo umano, misurato piuttosto che affermato
Quasi tutto ciò che si crede popolarmente riguardo al "metabolismo lento" è misurabile, e la maggior parte è stata misurata. I risultati non sono quelli che l'industria del benessere implica.
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The four things worth knowing
Adaptation
Does dieting damage your metabolism?
Adaptive thermogenesis is real and much smaller than the internet claims. A systematic review put a number on it.
Pathophysiology
Insulin resistance, mechanistically
What it is, what causes it, and why the popular carbohydrate story is incomplete.
Devices
Do CGMs tell healthy people anything?
Glucose variability in people without diabetes, and what a spike does and does not mean.
Thermogenesis
Brown fat and cold exposure
Genuinely fascinating physiology, and a very small contributor to human energy balance.
Tracking
Why calorie trackers disagree
Validity of dietary assessment against doubly labelled water — the error bars are enormous.
Letture correlate
GLP-1 Evidence
What the trials actually show about semaglutide, tirzepatide and the rest of the GLP-1 class.
Fasting Evidence
Intermittent fasting, time-restricted eating and meal timing, judged on the trial data.
Weight Loss Evidence
Diets, drugs, behaviour and maintenance — ranked by the strength of the evidence behind them.
Sleep Evidence
Sleep, circadian rhythm and the wearables that claim to measure both.
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